Sox2, a marker for stem-like tumor cells in skin squamous cell carcinoma and hedgehog subgroup medulloblastoma.
نویسندگان
چکیده
Heterogeneity within tumors is becoming increasingly recognized as an important cause of treatment failure in cancer. Two recent studies use fate-mapping and limiting dilution transplantation assays to identify SRY (sex determining region Y)-box 2 (Sox2) as cancer stem-cell marker and driver of cancer stemness.
منابع مشابه
Have you seen? Sox2, a marker for stem-like tumor cells in skin squamous cell carcinoma and hedgehog subgroup medulloblastoma
T here are several sources of tumor heterogeneity which include clonal evolution, heterogeneity in the microenvironment, and the hierarchical organization of certain cancers whereby highly tumorigenic cancer stem cells differentiate into less tumorigenic progeny (Meacham & Morrison, 2013). Employing genetic fatemapping and limited dilution transplantation analyses, two studies independently dis...
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عنوان ژورنال:
- The EMBO journal
دوره 33 18 شماره
صفحات -
تاریخ انتشار 2014